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Malignant disease
Malignant disease / Targeted therapy responsive malignancy
  everolimus Hospital Only
EVEROLIMUS

Hospital Use Only - Chair's action required
  imatinib [Specialist drug] On Formulary
  nilotinib [Specialist drug] Off Formulary
Malignant disease / Hormone responsive malignancy
  cyproterone acetate On Formulary
  ethinylestradiol On Formulary
  octreotide Hospital Only
OCTREOTIDE

For Hospital use only
Malignant disease / Cytotoxic responsive malignancy
  asparaginase [Specialist drug] On Formulary
  bleomycin [Specialist drug] On Formulary
Intralesional Bleomycin April 2016

BLEOMYCIN

For Hospital Use Only

  busulfan [Specialist drug] Hospital Only
  carboplatin [Specialist drug] On Formulary NICE TA284
NICE TA285
  Solution for infusion
Carboplatin (Non-proprietary) On Formulary
Carboplatin

For Hospital Use Only

  chlorambucil Hospital Only
CHLORAMBUCIL

For Hospital Use Only

  cisplatin [Specialist drug] On Formulary
  Solution for infusion
Cisplatin (Non-proprietary) On Formulary
Cisplatin

For Hospital Use Only

  clofarabine [Specialist drug] On Formulary
  crisantaspase [Specialist drug] On Formulary
  Powder for solution for injection
Erwinase (Porton Biopharma Ltd) On Formulary
  cyclophosphamide Hospital Only
CYCLOPHOSPHAMIDE

For Hospital Use Only

  Powder for solution for injection
Cyclophosphamide (Non-proprietary) On Formulary
Cyclophosphamide

For Hospital Use Only

  cytarabine [Specialist drug] On Formulary
Bart's Health Paediatric Oncology Guidelines

CYTARABINE

For Hospital Use Only

  Solution for injection
Cytarabine (Non-proprietary) On Formulary
Cytarabine

For Hospital Use Only

  dacarbazine [Specialist drug] Off Formulary
DACARBAZINE

For Hospital Use Only

  Powder for solution for injection
Dacarbazine (Non-proprietary) Hospital Only
Dacarbazine

For Hospital Use Only

  dactinomycin [Specialist drug] Off Formulary
  Powder for solution for injection
Cosmegen (Recordati Rare Diseases UK Ltd) Hospital Only
  daunorubicin [Specialist drug] Hospital Only
  doxorubicin hydrochloride [Specialist drug] On Formulary
  Solution for injection
Doxorubicin hydrochloride (Non-proprietary) Hospital Only
Doxorubicin

For Hospital Use Only

  Solution for infusion
Doxorubicin hydrochloride (Non-proprietary) Hospital Only
  epirubicin hydrochloride [Specialist drug] Hospital Only
EPIRUBICIN HYDROCHLORIDE

For Hospital Use Only

  Solution for injection
Epirubicin hydrochloride (Non-proprietary) Hospital Only
Epirubicin hydrochloride

For Hospital Use Only

Pharmorubicin (Pfizer Ltd) Hospital Only
Pharmorubicin® Solution for Injection

For Hospital Use Only

  Solution for infusion
Epirubicin hydrochloride (Non-proprietary) Hospital Only
  etoposide [Specialist drug] Hospital Only
ETOPOSIDE

For Hospital Use Only

Barts Health Paediatric Oncology Protocols

Paed Onc local Guidelines July 2014
  Powder for solution for injection
Etopophos (Neon Healthcare Ltd) On Formulary
Etopophos®

For Hospital Use Only

Barts Health Paediatric Oncology Protocols

Paed Onc Local Guidelines July 2014
  Solution for infusion
Etoposide (Non-proprietary) On Formulary
Etoposide

For Hospital Use Only

Barts Health Paediatric Oncology Protocols

Paed Onc Local Guidelines July 2014
  fludarabine phosphate [Specialist drug] Hospital Only
FLUDARABINE PHOSPHATE

For Hospital Use Only

  Solution for injection
Fludarabine phosphate (Non-proprietary) Hospital Only
FLUDARABINE PHOSPHATE

For Hospital Use Only

  Powder for solution for injection
Fludarabine phosphate (Non-proprietary) Hospital Only
FLUDARABINE PHOSPHATE

For Hospital Use Only

Fludara (Sanofi) Hospital Only
FLUDARABINE PHOSPHATE

For Hospital Use Only

  hydroxycarbamide On Formulary
Siklos - hydroxycarbamide tablet (paediatrics)

Siklos tablets can be used 2nd line in children with sickle cell disease if difficulty swallowing capsules.

Tablets are significantly more expensive than capsules.

SPC states 100mg Siklos tablets can be halved, and 1g tablets can be quartered for ease of dose rounding.
  ifosfamide [Specialist drug] On Formulary
  Powder for solution for injection
Ifosfamide (Non-proprietary) On Formulary
Ifosfamide

Hospital Use Only

  melphalan [Specialist drug] On Formulary
  mercaptopurine On Formulary
  Oral suspension
Xaluprine (Nova Laboratories Ltd) On Formulary
Xaluprine®

For Hospital Use Only

  methotrexate Hospital Only
Methotrexate

Hospital Use Only
Monitoring blood values while on methotrexate

see attached
Methotrexate Blood Monitoring Schedule

see attached
  mitotane [Specialist drug] Hospital Only
MITOTANE

For Hospital Use Only

  mitoxantrone [Specialist drug] On Formulary
  nelarabine [Specialist drug] Hospital Only
NELARABINE

For Hospital Use Only

  Solution for infusion
Atriance (Sandoz Ltd) On Formulary
Atriance®

For Hospital Use Only

  pegaspargase [Specialist drug] On Formulary NICE TA408
  procarbazine [Specialist drug] Hospital Only
PROCARBAZINE

For Hospital Use Only

  temozolomide [Specialist drug] Hospital Only
TEMOZOLOMIDE

For Hospital Use Only

  thiotepa [Specialist drug] On Formulary
  tioguanine [Specialist drug] Hospital Only
TIOGUANINE

For Hospital Use Only

  tretinoin [Specialist drug] On Formulary
  vinblastine sulfate [Specialist drug] On Formulary
  Solution for injection
Vinblastine sulfate (Non-proprietary) On Formulary
Vinblastine

Hospital Use Only

  vincristine sulfate [Specialist drug] On Formulary
Bart's Health Paediatric Oncology Guidelines

VINCRISTINE SULFATE

For Hospital Use Only

  Solution for injection
Vincristine sulfate (Non-proprietary) On Formulary
Vincristine

For Hospital Use Only

Malignant disease / Cytotoxic drug-induced side effects
  folinic acid On Formulary
FOLINIC ACID

For Hospital Use Only

  Solution for injection
Folinic acid (Non-proprietary) On Formulary
Calcium folinate

For Hospital Use Only

  levofolinic acid On Formulary
  mesna On Formulary
  Solution for injection
Mesna (Non-proprietary) On Formulary
MESNA

For Hospital Use Only

Malignant disease / Hyperuricaemia associated with cytotoxic drugs
  allopurinol On Formulary
  rasburicase On Formulary
  Powder and solvent for solution for infusion
Fasturtec (Sanofi) On Formulary
Fasturtec®

For Hospital Use Only

Malignant disease / Immunotherapy responsive malignancy
  interferon gamma-1b On Formulary
  Solution for injection
Immukin (Clinigen Healthcare Ltd) On Formulary
  mifamurtide [Specialist drug] On Formulary NICE TA235
Malignant disease / Secondary bone metastases and hypercalcaemia
  calcitonin (salmon) Off Formulary
  denosumab Off Formulary
Malignant disease / Antibody responsive malignancy
  Bevacizumab On Formulary
Bevacizumab

Bevacizumab (Avastin®)as intravitreal injection is approved for HOSPITAL ONLY use for Pre-threshold Retinopathy of Prematurity (ROP) 

Bevacizumab 0.625mg in 0.02ml given to each eye as per prescribing guidance
Intravitreal Bevacizumab (Avastin®) in Retinopathy of Prematurity

AS ATTACHED
  dinutuximab beta [Specialist drug] Off Formulary NICE TA538
  gemtuzumab ozogamicin [Specialist drug] Off Formulary NICE TA545
  ipilimumab [Specialist drug] Off Formulary
  rituximab Off Formulary
RITUXIMAB

For Hospital Use Only

  Solution for infusion
MabThera (Roche Products Ltd) Hospital Only
MabThera®

For Hospital Use Only