UKHSA Health Protection Briefing Note 2025/015: Two national hepatitis A clusters under investigation

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UKHSA and partner agencies have identified an increase in hepatitis A cases and are investigating two clusters of different viral genetic sequences of hepatitis A virus (HAV): VRD25_HAV017 and VRD25_HAV016 (with linked sequence VRD25_HAV049 which has a 1nt difference).

The majority of cases identified have been symptomatic, jaundiced and have required hospitalisation.

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